diff --git a/packages/react-openapi/src/OpenAPICodeSample.tsx b/packages/react-openapi/src/OpenAPICodeSample.tsx
index 8805b6fbb..e51501b1f 100644
--- a/packages/react-openapi/src/OpenAPICodeSample.tsx
+++ b/packages/react-openapi/src/OpenAPICodeSample.tsx
@@ -10,6 +10,7 @@ import { type OpenAPIContext, getOpenAPIClientContext } from './context';
 import { generateMediaTypeExamples, generateSchemaExample } from './generateSchemaExample';
 import { stringifyOpenAPI } from './stringifyOpenAPI';
 import type { OpenAPIOperationData } from './types';
+import { mergeHeaders } from './util/headers';
 import { getDefaultServerURL } from './util/server';
 import {
     resolvePrefillCodePlaceholderFromSecurityScheme,
@@ -125,10 +126,9 @@ function generateCodeSamples(props: {
     const mediaTypeRendererFactories = Object.entries(requestBody?.content ?? {}).map(
         ([mediaType, mediaTypeObject]) => {
             return (generator: CodeSampleGenerator) => {
-                const mediaTypeHeaders = {
-                    ...genericHeaders,
+                const mediaTypeHeaders = mergeHeaders(genericHeaders, {
                     'Content-Type': mediaType,
-                };
+                });
                 return {
                     mediaType,
                     element: context.renderCodeBlock({
diff --git a/packages/react-openapi/src/util/headers.test.ts b/packages/react-openapi/src/util/headers.test.ts
new file mode 100644
index 000000000..26feb501e
--- /dev/null
+++ b/packages/react-openapi/src/util/headers.test.ts
@@ -0,0 +1,116 @@
+import { describe, expect, it } from 'bun:test';
+import { mergeHeaders } from './headers';
+
+describe('mergeHeaders', () => {
+    it('should merge headers without conflicts', () => {
+        const baseHeaders = {
+            'user-agent': 'browser',
+            Authorization: 'Bearer token',
+        };
+        const overrideHeaders = {
+            'Content-Type': 'application/json',
+        };
+
+        const result = mergeHeaders(baseHeaders, overrideHeaders);
+
+        expect(result['user-agent']).toBe('browser');
+        expect(result.Authorization).toBe('Bearer token');
+        expect(result['Content-Type']).toBe('application/json');
+    });
+
+    it('should remove duplicate headers case-insensitively', () => {
+        const baseHeaders = {
+            'content-type': 'application/vnd.api+json',
+            'user-agent': 'browser',
+        };
+        const overrideHeaders = {
+            'Content-Type': 'application/json',
+        };
+
+        const result = mergeHeaders(baseHeaders, overrideHeaders);
+
+        // Should only have one Content-Type header (from override)
+        expect(result['Content-Type']).toBe('application/json');
+        expect(result['content-type']).toBeUndefined();
+        expect(result['user-agent']).toBe('browser');
+    });
+
+    it('should handle multiple case variations', () => {
+        const baseHeaders = {
+            'Content-Type': 'application/json',
+            'content-type': 'application/vnd.api+json',
+            'CONTENT-TYPE': 'text/plain',
+            'User-Agent': 'browser',
+        };
+        const overrideHeaders = {
+            'Content-Type': 'application/xml',
+        };
+
+        const result = mergeHeaders(baseHeaders, overrideHeaders);
+
+        // Should only have one Content-Type header (from override)
+        expect(result['Content-Type']).toBe('application/xml');
+        expect(result['content-type']).toBeUndefined();
+        expect(result['CONTENT-TYPE']).toBeUndefined();
+        expect(result['User-Agent']).toBe('browser');
+    });
+
+    it('should override headers with same key but different casing', () => {
+        const baseHeaders = {
+            'user-agent': 'old-browser',
+            'User-Agent': 'new-browser',
+        };
+        const overrideHeaders = {
+            'USER-AGENT': 'override-browser',
+        };
+
+        const result = mergeHeaders(baseHeaders, overrideHeaders);
+
+        // Should only have the override header
+        expect(result['USER-AGENT']).toBe('override-browser');
+        expect(result['user-agent']).toBeUndefined();
+        expect(result['User-Agent']).toBeUndefined();
+    });
+
+    it('should handle empty base headers', () => {
+        const baseHeaders = {};
+        const overrideHeaders = {
+            'Content-Type': 'application/json',
+            Authorization: 'Bearer token',
+        };
+
+        const result = mergeHeaders(baseHeaders, overrideHeaders);
+
+        expect(result['Content-Type']).toBe('application/json');
+        expect(result.Authorization).toBe('Bearer token');
+    });
+
+    it('should handle empty override headers', () => {
+        const baseHeaders = {
+            'Content-Type': 'application/json',
+            Authorization: 'Bearer token',
+        };
+        const overrideHeaders = {};
+
+        const result = mergeHeaders(baseHeaders, overrideHeaders);
+
+        expect(result['Content-Type']).toBe('application/json');
+        expect(result.Authorization).toBe('Bearer token');
+    });
+
+    it('should preserve override header casing', () => {
+        const baseHeaders = {
+            'content-type': 'application/json',
+        };
+        const overrideHeaders = {
+            'Content-Type': 'application/xml',
+        };
+
+        const result = mergeHeaders(baseHeaders, overrideHeaders);
+
+        // Should use the casing from override headers
+        expect(result['Content-Type']).toBe('application/xml');
+        expect(Object.keys(result)).toContain('Content-Type');
+        expect(Object.keys(result)).not.toContain('content-type');
+    });
+});
diff --git a/packages/react-openapi/src/util/headers.ts b/packages/react-openapi/src/util/headers.ts
new file mode 100644
index 000000000..432a73267
--- /dev/null
+++ b/packages/react-openapi/src/util/headers.ts
@@ -0,0 +1,18 @@
+/**
+ * Merges two header objects, removing duplicate headers case-insensitively.
+ * Headers from the second object take precedence over headers from the first object.
+ */
+export function mergeHeaders(
+    baseHeaders: Record<string, string>,
+    overrideHeaders: Record<string, string>
+): Record<string, string> {
+    const overrideKeysLower = new Set(Object.keys(overrideHeaders).map((key) => key.toLowerCase()));
+    const filteredBaseHeaders = Object.fromEntries(
+        Object.entries(baseHeaders).filter(([key]) => !overrideKeysLower.has(key.toLowerCase()))
+    );
+
+    return {
+        ...filteredBaseHeaders,
+        ...overrideHeaders,
+    };
+}